Phil Jones could also be available as United manager Sir Alex Ferguson once again prepares to rotate his squad.
Ferguson noted Michael Carrick was particularly tired after Saturday's win at West Brom, whilst top scorer Robin van Persie seems certain to be recalled.
The New Year's Day clash is expected to come too soon for Wigan's Antolin Alcaraz as he continues his recovery from a groin problem.
Antonio Lopez, Ben Watson, on-loan Arsenal winger Ryo Miyaichi and Albert Crusat are also absent with injury.
Both Ivan Ramis and Franco Di Santo are available for selection for the Latics after making their returns against Villa.
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